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June 13, 1936


JAMA. 1936;106(24):2089. doi:10.1001/jama.1936.02770240053024

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To the Editor:—  The editorial on the potency of antianemic preparations in The Journal, April 11, prompts me to comment on the obvious inadequacy of the method for determining the quantitative potency of liver substitutes prescribed by the Council on Pharmacy and Chemistry.Determination of the potency of such substances, as specified by the Council, is to be made on the basis of the magnitude of the reticulocyte response induced by the administration of the liver substitute. Although such a response has been used as an indication of qualitative potency of liver and substitutes for it since the introduction of liver therapy, it has been almost uniformly recognized that the magnitude of this response is not necessarily a measure of the power of a substance to produce erythrocytes, which is the fundamental problem concerned in the treatment of pernicious anemia. Not only will certain substances not effective in stimulating erythrocytes

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