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June 13, 1936

Modification of the Virulence of Tubercle Bacilli

JAMA. 1936;106(24):2095-2096. doi:10.1001/jama.1936.02770240059029

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This monograph (an English translation) details the work carried out in the State Veterinary Serum Laboratory during 1925 to 1930 and contains an extensive review of the literature, with a bibliography of 129 references. The survey forms a continuation of a previous monograph by the author on avian tuberculosis in mammals, in 1925-1926. Twelve charts on experimental data are included. The work has been painstaking in detail and the author admits many possibilities for error in results and interpretation. The problem was to make avian tubercle bacilli virulent for mammals and to make mammalian tubercle bacilli virulent for fowls. The cultural properties of tubercle bacilli are reviewed and cases recorded in which mammalian tubercle bacilli were demonstrated in birds and avian tubercle bacilli in mammals. Mixtures of bovine and avian tubercle bacilli are inoculated through several generations of guinea-pigs, rabbits and hens, and it was found possible to separate the

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