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This monograph is based on a systematic study of the bronchial tree in primary carcinoma of the lung. In a number of cases a tendency to the development of many carcinomatous formations in the bronchial lining was established. A definite change in the bronchial epithelium in one or several places outside the main growth was demonstrated in more than a third of the cases studied. Such changes were found in the flat cell variety of carcinoma; it was not found in adenocarcinoma. The author emphasizes that he found only minute multiple carcinomas in addition to the large carcinoma and no other macroscopically recognizable primary growths with only one exception, in which case each lung was the seat of a primary carcinoma about as large as a fist. It seems as if the possibility must be considered that at least many of the small carcinomas developed long before death but that
Über die formale Genese des Lungenkrebses. JAMA. 1936;106(24):2097. doi:10.1001/jama.1936.02770240061035