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August 29, 1936

Experimentelle Undersøgelser over en transplantabel Leukose hos hvide Mus

JAMA. 1936;107(9):740. doi:10.1001/jama.1936.02770350108037

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This doctorate thesis deals with the details of experiments on a transmissible leukosis in white mice, starting in a spontaneous instance. Successful transmission was obtained by subcutaneous or intravenous injection of leukosis cells in mice after roentgenization or injection of trypan blue. The peculiar cells were round and of varying size, a narrow rim of basophilic, nongranular cytoplasm enclosing a round or curved nucleus with a fine chromatin network and from two to five nuclei. These cells occurred in varying numbers in the blood as well as in local growths and infiltrations; there also developed myeloid hyperplasia in the marrow and spleen. Comparing this instance with previously described forms of transmissible mammalian leukosis, it appears that Korteweg observed a similar variety in 1929. These two instances are peculiar mainly in that a sudden neutrophil leukocytosis developed before the appearance in the blood of the characteristic cells. As in other forms,

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