Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Carr and colleagues1 found that abacavir was associated with a modest
increase in limb fat among adults with human immunodeficiency virus (HIV)–related
lipoatrophy. However, there was a wide variation in baseline levels of fasting
plasma insulin and triglycerides among the subjects, as reflected by the large
SDs that were almost equal to and sometimes exceeded the corresponding means.
There was less variation in the baseline anthropometric parameters, which
does not fully explain such wide variation in insulin and triglyceride measures.
On the other hand, mean levels of fasting plasma glucose were within the normal
range, and associated with small SDs.
Mikhail N. Insulin Resistance and HIV-Related Lipoatrophy. JAMA. 2002;288(14):1716. doi:10.1001/jama.288.14.1716