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January 26, 1946


JAMA. 1946;130(4):212. doi:10.1001/jama.1946.02870040028009

Recently Salk and his colleagues1 reported the efficacy of vaccination against influenza, using a preparation which contained larger quantities of virus than usually employed, with the purpose of producing a higher degree of immunity. More than 2,000 persons at the Ypsilanti State Hospital in Michigan were studied. At the Eloise Hospital Infirmary 5,737 persons were involved. At the Ypsilanti State Hospital alternate persons in certain wards who were selected for study received a subcutaneous injection of 1 cc. of the virus vaccine or a similar inoculation of control material. One thousand and thirty-five were given the vaccine and 1,051 received the control inoculation. This took place on Dec. 21 and 22, 1942. Between Jan. 5 and 12, 1943 2,879 received the vaccine and 2,858 received control material at the Eloise Hospital and Infirmary. Blood for serologic study was obtained from approximately 10 per cent of the vaccinated group at

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