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February 16, 1946

The Medical Use of Sulphonamides

JAMA. 1946;130(7):463. doi:10.1001/jama.1946.02870070083031

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As the authors state in the introduction, it was thought desirable to prepare a concise review of the clinical indications for some of the principal sulfonamide drugs in the light of their current or potential availability in Great Britain. Since the appearance of the first edition in 1943 rapid advancements have been made in this field of therapy, and a concise and authoritative revision, such as the present revision reflects, is highly desirable. This compact work reviews the chemistry, pharmacology and general principles of sulfonamide therapy. In addition there is a discussion of the relationship of sulfonamide therapy to penicillin. Treatment of various infectious diseases are detailed, and the limitations of this type of therapy are stressed. Pertinent references to the extensive literature on the subject are interspersed throughout the text. Although American clinicians will not be in complete agreement with some of the statements, particularly with reference to the

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