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To the Editor:—
The term "retrograde injection," when it is used with reference to varicose veins, is ambiguous. The ambiguity arises from the fact that the flow of blood in varicose veins is reversed (Trendelenburg positive). Consequently a type of injection which, if made into a normal vein, would be properly designated "retrograde" (against the normal direction of flow) could not be so designated if the injection should be made into a varicose vein in which the flow was reversed. However, I doubt if authors or readers generally will keep in mind the suggested distinctions and, for clearness, I believe it will be necessary for authors who use the word "retrograde" in writing of varicose veins to explain their use of it.
Smith FL. RETROGRADE INJECTION. JAMA. 1946;130(12):815. doi:10.1001/jama.1946.02870120061025