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The hepatorenal syndrome is a constellation of clinical manifestations caused by a toxic or infectious agent acting simultaneously on the liver and the kidney. The authors state that there is no single causative factor and that no uniform anatomic basis exists for this syndrome except coincidental involvement of the two organs. The individual signs and symptoms of this purely clinical concept are then discussed in some detail. The syndrome consists essentially of jaundice, enlargement of the liver, albuminuria and retention of urea in the blood. Various additional features may be present, such as hemorrhages, nervous phenomena and, less often, generalized edema or hemolytic changes. The syndrome, being due to any one of a large variety of causes, has a variable prognosis, and treatment is directed to the cause as well as to the more important presenting signs or symptoms. Although it is doubtful whether a conception of a disease entity
Les hépatonéphrites. JAMA. 1937;109(5):385-386. doi:10.1001/jama.1937.02780310063032