In 19331 five cases of lycopodium granuloma were reported. In these instances the spores of lycopodium clavatum, an ingredient of dusting powder used for gloves, had been introduced into the operative field in the course of surgical procedure. These acted as foreign bodies and gave rise to indolent chronic postoperative inflammatory reactions at the original operative site and necessitated secondary operations at a subsequent date. Six similar cases, in which the spores were also introduced during operative procedures, were described by Erb2 in 1935.
In the original communication1 it was shown that this substance either impeded the abatement of the existing condition or gave rise to additional complicating factors, and inferentially the use of lycopodium spores as a component of dusting powder on operative implements was cautioned against.
Since that time another instance of lycopodium granuloma has been encountered in which the mode of introduction varied from the modes
Antopol W, Robbins C. LYCOPODIUM GRANULOMA RESULTING FROM THE USE OF ANAL SUPPOSITORIES. JAMA. 1937;109(15):1192. doi:10.1001/jama.1937.92780410001008