Author Affiliations: MRC Epidemiology Unit, Addenbrookes Hospital, Cambridge, United Kingdom (Dr Ekelund; email@example.com); School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (Dr Sherar); and Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, United Kingdom (Dr Cooper).
In Reply: Dr Chaput and colleagues argue that it is premature to conclude that sedentary time is not associated with cardiometabolic health outcomes in children. Our study concluded that “higher levels of time in MVPA appear to be associated with better cardiometabolic risk factors regardless of the amount of time spent sedentary in youth.” Our conclusion was strongly supported by the data, but we do not dismiss a potential role of specific sedentary behaviors in relation to cardiometabolic risk. The association between time in MVPA and cardiometabolic risk factors was strong, consistent in both continuous and stratified analyses, and the magnitude of the association did not materially change following adjustment for sedentary time. However, sedentary time was not associated with cardiometabolic risk markers following mutual adjustment for time in MVPA.
Ekelund U, Sherar L, Cooper A. Time Spent Sedentary and Active and Cardiometabolic Risk Factors in Children—Reply. JAMA. 2012;307(19):2024-2025. doi:10.1001/jama.2012.3657