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October 28, 1939


JAMA. 1939;113(18):1631-1634. doi:10.1001/jama.1939.02800430023006

The encouraging results of sulfanilamide therapy in infections caused by the hemolytic streptococcus, the meningococcus, the colon bacillus and the gonococcus, and the more recent results of sulfapyridine therapy in pneumococcic pneumonia have made us hopeful that eventually some such chemotherapeutic agent might be discovered which would influence the course of pulmonary tuberculosis in a favorable manner. The reports from England as well as those from America have indicated that sulfapyridine is an impressive drug, powerful in effecting a cure in pneumonia yet relatively nontoxic as far as permanent harm or death of the patient is concerned. We felt that this drug might have some bactericidal effect on the tubercle bacillus, and since there had been no reports on its use in treating tuberculosis we decided in December 1938 on the investigation which we are now reporting. Recently there has appeared in the literature a paper on the effects of

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