Author Affiliations: Case Western Reserve University School of Medicine and Rainbow Babies and Children's Hospital, Cleveland, Ohio (Drs Dasenbrook and Konstan).
In the past 70 years, survival of patients with cystic fibrosis (CF) has improved substantially.1 However, median predicted survival is only 38 years of age.2 Extending life expectancy to that of healthy individuals would presumably require initiating treatment in early infancy before the onset of irreversible lung damage. The recent advent of universal newborn screening for CF provides this opportunity.
Dasenbrook EC, Konstan MW. Inhaled Hypertonic Saline in Infants and Young Children With Cystic Fibrosis. JAMA. 2012;307(21):2316–2317. doi:10.1001/jama.2012.5853