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January 6, 1940


JAMA. 1940;114(1):43. doi:10.1001/jama.1940.02810010045012

In 1936 Szent-Györgi and his collaborators1 established the presence in extracts of Hungarian red pepper and later in lemon juice of substances other than ascorbic acid which could control the hemorrhage that occurs in the course of a variety of conditions Ascorbic acid, even in excess, was ineffective. Later it was reported from the same laboratory2 that fractionation of the curative extracts had demonstrated that the active substance was present in a fraction consisting of practically pure flavone or flavone glucoside. The potency of the latter fraction was confirmed by the demonstration that the continued daily intravenous administration of the concentrate in clinical cases that were characterized by an increased permeability or fragility of the capillary wall restored the normal capillary resistance in a relatively short time. The results led to the suggestion that the large group of vegetable pigments the flavones or flavonals have an important part

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