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January 20, 1940

LIPOID PNEUMONIA

JAMA. 1940;114(3):251-252. doi:10.1001/jama.1940.02810030051015
Abstract

In 1925 Laughlen,1 of Toronto, described four cases of bronchopneumonia in infants with an unusual microscopic picture. In addition to the usual polymorphonuclear leukocytic exudate, an exudate was present consisting almost exclusively of large vacuolated mononuclear cells containing unstained droplets of various sizes. By the use of sudan III stain these globules were demonstrated to be oil. Laughlen saw a similar condition in a man of 37 with paralysis of the vocal cords. This patient was given 1 1/2 ounces (45 cc.) of liquid petrolatum three times a day for four and onehalf months as a laxative. At necropsy a condition similar to that in the preceding four cases was present in his lungs. In all of Laughlen's five cases there was a history of "oil treatment." In three menthol in liquid petrolatum was administered in intranasal drops and in two liquid petrolatum was given as a laxative.

Laughlen

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