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January 20, 1940


JAMA. 1940;114(3):272. doi:10.1001/jama.1940.02810030072026

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To the Editor:—  I read with interest the article by Walter McMann on Hypersensitivity to Solution of Posterior Pituitary. This appeared on page 1488 of the Oct. 14, 1939, issue. He stresses its rarity, which prompts me to cite the following case: In the fall of 1939 one of my patients was given 3 minims (0.2 cc.) of solution of posterior pituitary, and about ten or fifteen minutes later a generalized, pruritic, urticarial eruption developed with collapse. In an hour or so this attack disappeared following the use of 1 cc. of epinephrine 1:1,000 in divided doses. She had previously had a localized redness at the site of a similar injection given during the treatment of obesity. No other allergic fact was noted.

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