Pain is the most common complaint in arthritis, neuralgia and related conditions. These ailments at times may be dominated by discomfort so intractable as to subordinate all other considerations until symptomatic relief is provided for the patient. Failure or delay of the clinical measures in giving adequate comfort in such situations presents a not infrequent and difficult therapeutic problem.
The relief of pain in arthralgia and neuralgia for these reasons has been the subject of investigation in our clinic for several years. The current interest in the use of venoms for relief of pain, particularly in rheumatic disease, leads us to publish this preliminary report on our therapeutic experience with cobra toxin. Our studies are continuing and will in time cover the treatment of a larger group of patients than are represented here. Among other remedies, we have observed the effects of copperhead and rattlesnake extracts. These substances were in
STEINBROCKER O, McEACHERN GC, LaMOTTA EP, BROOKS F. EXPERIENCE WITH COBRA VENOM IN THE ARTHRALGIAS AND RELATED CONDITIONS. JAMA. 1940;114(4):318-322. doi:10.1001/jama.1940.02810040028008