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January 27, 1940

Heparin: Its Chemistry, Physiology and Application in Medicine

JAMA. 1940;114(4):350. doi:10.1001/jama.1940.02810040060034

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This little book, appropriately dedicated to Prof. William H. Howell, in whose laboratory the original work on heparin was carried out, is a most useful review of our present knowledge of the subject. The chapters on the chemistry of heparin and those on the probable site of its formation, the mast cells of Ehrlich, give a coordinated picture of the brilliant researches which have been recently carried out in Stockholm by Jorpes and his collaborators. These results are of great interest not only to the physiologist and biochemist but also to the histologist, who has been in doubt as to the function of these mast cells ever since their discovery. While, as is natural, the work carried out in Stockholm is described in considerable detail, adequate reference is made to the original work in Professor Howell's laboratory, to the chemical and physiologic contributions from Toronto and to work in many

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