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February 3, 1940


JAMA. 1940;114(5):386-393. doi:10.1001/jama.1940.02810050006002

During the past eight months we have observed nine children, almost all of families on relief, attending the pediatric outpatient department, with cutaneous lesions of vitamin A deficiency similar to those described by Frazier and Hu1 in Chinese soldiers, by Loewenthal2 and by Nicholls3 in prisoners in Africa and India respectively, and in various parts of the world by other observers.4 In the United States Scheer and Keil5 recorded two cases of scurvy in which these lesions also were present and Jeghers6 described cutaneous manifestations in medical students that he had observed for impaired dark adaptation. Also Youmans and Corlette7 reported a series of cases in which these cutaneous lesions were present and Steffens, Bair and Sheard8 experimentally produced this dermatosis in a healthy human subject.

CLINICAL MANIFESTATIONS  The dermal lesions of our children were symmetrical and located chiefly on the

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