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February 17, 1940


JAMA. 1940;114(7):602. doi:10.1001/jama.1940.02810070067025

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To the Editor:—  In 1936 I got in touch with Dr. Wolffe, after seeing the type of work he was doing with various fractions of pancreatic extract, and asked him to prepare an exhibit for the 1937 meeting of the New Jersey State Medical Society.Dr. Wolffe and his colleagues showed conclusively that the pancreas contained hormones which differ from insulin. One they described as having an epinephrine neutralizing effect. This had previously been shown by a number of investigators, such as Frey and Kraut, Gley and Kisthinios, and Vaquez and his co-workers. Dr. Wolffe's group demonstrated modifications of the previously reported method of preparation of this particular fraction, its possible isolation and new methods for standardization. They gave due credit to the previous investigators.In their exhibit they also showed that the pancreas contains a hormone which influences fat metabolism and which to the best of their knowledge had

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