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March 23, 1940

QUININE TREATMENT OF DYSTONIA MUSCULORUM

JAMA. 1940;114(12):1068. doi:10.1001/jama.1940.62810120004010c

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Abstract

In a recent article Hassin1 reported treatment of three cases of dystonia musculorum with quinine with definite relief of the excessive involuntary, uncontrollable movements characteristic of this disorder. Because this disorder is rare and because of the marked benefit obtained with quinine, it was felt that the following case should be reported:

History.—  A woman aged 23, single, who had to be assisted into the office because of twisting, writhing movements of the extremities, head and trunk, had a blister on the left foot at about the age of 11, followed by weakness of the left ankle and pain in the left knee and hip. Disability of the left leg gradually developed, with the onset of twisting contortions of the back and neck during the past three years. The torsion spasms of the trunk had become so bad that she could not walk without assistance and was confined

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