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April 6, 1940


JAMA. 1940;114(14):1320-1321. doi:10.1001/jama.1940.02810140020005

In August 1938 I began to use dilantin sodium in the treatment of epilepsy, gradually adding patients as I went along. This report concerns forty-eight cases. The patients were not selected but rather were chosen at random. They were of all ages, the etiology in all of the cases being unknown. All of these patients had received either phenobarbital or bromide or both for long periods, but the convulsions continued despite this form of medication. Various forms of diet were also tried at various times but without improvement. At the time of this writing all of the patients have the same diet. The duration of their epilepsy varied from one to thirty-one years and the frequency of convulsions from one to seventy-four a month, and many of the patients suffered from attacks of both grand and petit mal. All of the patients who were following some form of occupation have

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