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April 6, 1940

COMPARATIVE EFFECTS OF PHENOBARBITAL AND DILANTIN SODIUMIN THE TREATMENT OF EPILEPSY

JAMA. 1940;114(14):1334-1335. doi:10.1001/jama.1940.02810140034009
Abstract

This paper embodies observations on the comparative effects of phenobarbital and dilantin sodium in the treatment of epilepsy.

Material for this study comprised a group of 100 patients at the Monson State Hospital, who were selected on the basis of frequency and regularity of convulsive attacks regardless of diagnosis, age, sex, age of onset, duration of attacks, mental status, physical condition or previous medication. The vast majority of the patients had been having ten or more seizures per month regularly. Medication previous to this study had consisted of phenobarbital in doses of 3 grains (0.2 Gm.) or less daily.

The effect of treatment by phenobarbital or dilantin sodium was evaluated on the basis of effect on seizures, salutary effects, effects on the general condition of the patient, and untoward effects. The therapeutic response was graded as follows:

Group 1. Complete control of, or marked reduction in the number of seizures,

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