As early as 18781 the association between gallbladder disease and heart disease was noted. Much recent comment, preponderantly favoring a significant relation between the two, has appeared in the literature. Many of these contributions have indicated a more than incidental relationship between cholecystic disease and coronary artery disease, although some authors deny that such a connection exists.
In 1935 eighty-eight cases of coronary artery disease with necropsy showing a striking frequency of gallbladder disease were reported from this laboratory.2 This series was small and had not been subjected to biometric study. Moreover, neither the age incidence nor the freqeuncy of gallbladder disease not combined with coronary artery disease had been determined for comparison. Therefore a larger series of necropsies was subjected to critical analysis with attention to all of the foregoing points.
To determine accurately what significance there might be, if any, in the coexistence of gallbladder disease
BREYFOGLE HS. THE FREQUENCY OF COEXISTING GALLBLADDER AND CORONARY ARTERY DISEASEA STATISTICAL ANALYSIS AND BIOMETRIC EVALUATION OF 1,493 NECROPSIES. JAMA. 1940;114(15):1434–1437. doi:10.1001/jama.1940.02810150020006