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To the Editor:—
In the report of the Council on Pharmacy and Chemistry dealing with "The Present Status of Therapy with Chorionic Gonadotropin," which appeared in The Journal, February 10, page 487, the statement was made that "Rubinstein claims that the sperm counts increased following such therapy. His results are statistically unconvincing." Since to the uncritical reader such a statement is interpreted as being synonymous with a misrepresentation of facts, may I take this opportunity to make several additional observations? In my original article (Endocrinology23:75 [July] 1938), which reported studies on six healthy adults, no attempt at statistical analysis was made because it was felt that spermatozoal counts differed so much between the different patients and was so inconstant even in the same patient for similar interval periods that a grouped comparison would hardly be in order. From the data obtained, however, it was concluded that after varying
Rubinstein HS. PRESENT STATUS OF THERAPY WITH CHORIONIC GONADOTROPIN. JAMA. 1940;114(15):1477-1478. doi:10.1001/jama.1940.02810150063023