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To the Editor:—
A recent local epidemic of scarlet fever followed by a number of endemic cases has given an opportunity for a study of the use of sulfanilamide as prophylaxis to children exposed to scarlet fever. At first it was used only in cases in which the cost of the scarlet fever antitoxin was prohibitive or it was feared that some reaction might attend the use of the antitoxin. Later, when it was seen that the use was successful in the prevention of the disease, it was used in all cases of exposure. To date in only one person of 116 exposed has scarlet fever developed after the use of sulfanilamide, and in this one exception the person had been exposed five days previously and the fever developed the day following the start of the drug.Perhaps the most spectacular instances and the two that started the use of
Jewell LE. THE USE OF SULFANILAMIDE AS PROPHYLAXIS FOR SCARLET FEVER. JAMA. 1940;114(15):1478. doi:10.1001/jama.1940.02810150064025