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May 4, 1940

ENCEPHALITIS IN INFANTS AND CHILDRENCAUSED BY THE VIRUS OF THE EASTERN VARIETY OF EQUINE ENCEPHALITIS

JAMA. 1940;114(18):1725-1731. doi:10.1001/jama.1940.02810180001001
Abstract

During a period of six weeks beginning Aug. 26 and ending Sept. 11, 1938, eight patients were admitted to the Infants' Hospital and to the Children's Hospital suffering from a severe form of encephalitis. Studies performed on one of these patients (J. M.) led to the identification of the causative agent as the virus of the eastern type of equine encephalitis and to the recognition of a new disease affecting man.1 The occurrence of human encephalitis caused by the virus of equine encephalitis has been suspected since 1932.2 These patients formed part of a group of approximately thirtyeight infants, children and adults in Massachusetts who probably suffered from this disease in late August and September 1938. The mortality rate for the entire group was 65 per cent. Sixty-nine per cent of those affected were under 10 years of age.3 The clinical and pathologic data of eight patients

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