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May 18, 1940


JAMA. 1940;114(20):2002-2010. doi:10.1001/jama.1940.62810200007008a

THE RELATIONSHIP OF CERTAIN VITAMINS TO HORMONES  A close physiologic interrelationship is said to exist between certain hormones and vitamins. The various sex hormones are related to vitamin D in their chemical structure, since "cholesterol may be converted into the male sex hormone; the male sex hormone is readily convertible to estrone and this in turn to progesterone. Testosterone is very similar structurally to ergosterol and vitamin D."97Vitamin A has been found to exert an antagonistic action on thyroxine, as has been demonstrated by various experiments in animals and human beings.98 These investigators have shown that thyrotoxicosis can be cured and prevented with a diet rich in vitamin A. Conversely, hypervitaminosis A could be prevented and cured by ingestion of desiccated thyroid. Since the original work of Von Euler and Klussmann,98d it is generally believed that the growth factor which is contained in vitamin A is

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