In 1893 Vidal1 described a generalized symmetrical eruption involving the nails in a patient with gonorrheal polyarthritis. In 1912 Simpson2 described the first case occurring in the United States. Keim3 in 1924 observed and recorded a similar case in which he made minute microscopic studies and reviewed all the pertinent literature, analyzing the disease from an etiologic angle and differentiating it from pustular psoriasis. Since 1924 there have been numerous additions to our knowledge of this syndrome, particularly concerning its response to treatment. Our purpose is to review briefly the more recent literature and to record studies made on two patients who have been under our care at Bellevue Hospital.
The genesis of keratosis blennorrhagica has been discussed by Génner and Boas,4 Scomazzoni,5 Rostenberg and Silver6 and Ormsby in the discussion of a paper by Ebert and Slepyan,7 the consensus being that
COMBES FC, DIETRICH C, COHEN J. KERATOSIS BLENNORRHAGICAA BRIEF REVIEW AND REPORT ON THE EFFECTS OF HYPERPYREXIA IN ITS TREATMENT. JAMA. 1940;114(21):2078–2082. doi:10.1001/jama.1940.02810210010003