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May 25, 1940


JAMA. 1940;114(21):2118-2119. doi:10.1001/jama.1940.02810210050018

As a result of the rapidly developing information concerning this substance during recent years, heparin, from being a rather unique anticoagulant with limited laboratory application, has become a promising clinical adjunct. The isolation of a highly purified product has contributed to the advance in our knowledge of this substance. The rapidly accumulating information regarding heparin has recently been reviewed by the Scandinavian investigator Jorpes.1

With the purified product available, organic chemists have made progress in establishing the chemical structure of the heparin molecule. Thus Charles and Todd2 have studied the crystalline barium salt of heparin which was isolated from heparin preparations made from beef lung, beef liver and beef intestine. All these crystalline barium salts are similar in their composition and physiologic potency. Charles and Todd, after careful observations of the chemical behavior of heparin and on the basis of previous work, have concluded that heparin is a

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