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June 1, 1940

CONFERENCES ON THERAPYTREATMENT OF BLOOD DISORDERS

JAMA. 1940;114(22):2207-2214. doi:10.1001/jama.1940.62810220012007b

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Abstract

I. IRON THERAPY

Dr. Eugene F. Du Bois:  The conference today is the first of a series on the treatment of blood disorders. We hope that the plan of pursuing through several sessions a topic of limited scope will result in a more comprehensive discussion of the subject and perhaps also permit more time for informal discussion. We begin with iron therapy, and Dr. Warren will discuss the metabolism of iron with special reference to the red blood cells and hemoglobin.

THE METABOLISM OF IRON 

Dr. Charles O. Warren Jr.:  We shall start by recalling the structure of the hemoglobin molecule, which, as you will remember, is made up of a "heme" part consisting of four substituted pyrrol groups and an atom of iron all linked together and combined with the protein globin. Apparently the body can synthesize the hemoglobin molecule from groups even simpler than the pyrrol nuclei, but

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