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June 8, 1940

INCIDENCE AND INTERPRETATION OF DIABETIC-LIKE DEXTROSE TOLERANCE CURVESIN NERVOUS AND MENTAL PATIENTS: A STUDY OF SIXTY-NINE SUCCESSIVE ADMISSIONS PRELIMINARY REPORT

JAMA. 1940;114(23):2279-2284. doi:10.1001/jama.1940.02810230009003
Abstract

The relationship between disorders of the nervous system and the metabolism of the human organism has been the subject of much clinical and experimental study. The discovery of a carbohydrate catalyst, insulin, in 1923 made it possible for Sakel in 1933 to publish his revolutionary monograph on the treatment of schizophrenia with hypoglycemic shock induced by insulin. Appel, Farr and Marshall,1 Bennett and Semrad,2 Ziskind and Somerfeld-Ziskind3 and others have reported beneficial effects from the use of small doses of insulin in various psychotic reactions of both the functional and the organic reaction types. We have observed beneficial effects from small doses of insulin and a high carbohydrate intake on such conditions as mild schizophrenia, psychoneurosis, chronic alcoholism, delirium tremens and arteriosclerotic conditions. We have reported on the use of insulin in the treatment of delirium tremens,4 confirming the reports of Klemperer,5 Puyuelo Salinas6

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