In March 1931, as already reported,1 a man aged 51 acutely ill with hemophilia was treated by venesection. In forty-eight hours he was almost free from symptoms. For long intervals he had been completely incapacitated because of joint symptoms occurring with the hemophilia. After this the patient, on the onset of symptoms, would come in for venesection on an average of about once every six weeks. From 400 to 500 cc. of blood was removed each time. The last venesection done by us was on June 23, 1939, when he was apparently in good physical condition except for nervousness and marked apprehension of death. He had been in rather good condition as a whole during the many years that we had been bleeding him, except for some discomfort in one knee. The x-ray film of this knee showed small cystic looking areas in the patella and lower femur.
Lawson GB, Graybeal AB. HEMOPHILIA TREATED BY VENESECTION. JAMA. 1940;114(23):2299-2300. doi:10.1001/jama.1940.62810230002007a