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The author accepts as proved the existence in the human organism of neurohumoral substances, chemical factories of nervous stimulation. Sympathin and vagus substance have been demonstrated in experiment by many investigators. These substances are demonstrable in normal states when the vegetative nervous system is stimulated or when one of its functions is interfered with. The oculocardiac phenomenon of Aschner offers a convincing illustration. The presence of the vagus substance can be demonstrated in the blood when this phenomenon is positive. The classic experiments of Loewi and the contributions of Dale and Cannon demonstrated that formation of chemical substances accompanies the reflex activity of the vegetative nervous system under normal conditions. Some of these substances may act as vasodilators or as vasoconstrictors and cause an imbalance in a given vascular area. In the course of a number of years of study of tissue metabolism the author and his co-workers at the
Khimicheskaya priroda nervnogo vozbuzhdeniya v organizme cheloveka. JAMA. 1940;114(23):2328. doi:10.1001/jama.1940.02810230058032