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June 15, 1940

ROLE OF ALKALI THERAPY FOR PEPTIC ULCER IN FORMATION OF URINARY CALCULI

JAMA. 1940;114(24):2363-2366. doi:10.1001/jama.1940.02810240017006
Abstract

When peptic ulcer is treated by the customary methods, which involve the ingestion of large amounts of alkaline powders, several conditions are produced which are generally accepted as important etiologic factors in the formation of urinary calculi. It has been shown1 that during a Sippy type of treatment the urinary excretion of solids is doubled, the specific gravity of the urine is high (the average twenty-four hour specimen having a specific gravity of 1.020) and the pH of the urine is shifted to the alkaline side. These three conditions have been mentioned many times as important etiologic factors in the development of kidney stones. Because peptic ulcer is a common disease and because the use of large amounts of alkali is a popular form of treatment, it would be expected that in any large series of patients with urinary lithiasis there would be a significant number who had

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