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June 15, 1940


JAMA. 1940;114(24):2366-2368. doi:10.1001/jama.1940.02810240020007

It was stated recently in The Journal1 that "fifteen years ago Ramon and Laffaille2 suggested a new method of prophylaxis against diphtheria. By this improved method the transient passive immunity caused by injecting antitoxic serum is supplemented by a semi-permanent active immunity caused by the simultaneous injection of diphtheria toxoid." Then Frey and Schmid's3 work on the subject was referred to and this conclusion was drawn: "Combined active-passive immunization is not feasible in human medicine, the two types of immunization being incompatible with each other." It was stated: "Frey and Schmid injected 2,000 units of antidiphtheritic serum... into each of twenty children, followed by single or multiple subcutaneous injection with diphtheria toxoid," whereas in the original text Frey and Schmid stated that their patients received 1,000 or 2,000 antitoxic units intramuscularly simultaneously with 1 cc. of alum toxoid (unsere Patienten erhielten 1.000 bzw. 2.000 Anti-toxineinheiten intramuskulär sowie

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