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June 29, 1940

THE USE OF DESOXYCORTICOSTERONE ACETATE IN ADDISON'S DISEASE

JAMA. 1940;114(26):2530-2537. doi:10.1001/jama.1940.02810260016004
Abstract

Desoxycorticosterone acetate is one of several synthetic adrenal cortical hormones. It was produced by Steiger and Reichstein1 and announced in 1937. More recently, its existence in beef adrenals has been shown by Reichstein and von Euw.2 Reports dealing with the clinical use of this material have been published by Levy-Simpson,3 Levy-Simpson, Wilkinson, Himsworth and Jones,4 Cleghorn, Fowler and Wenzel,5 Thorn, Howard and Emerson6 and Zahler and Litzka.7 Corticosterone is apparently identical with Kendall's8 substance B.

We have treated six cases of Addison's disease with this material for periods ranging from six to ten months. Except for brief periods of observation, such treatment has been combined with the use of sodium chloride as enteric coated tablets, in doses varying from 3 to 16 Gm. per day.9 At first potassium intake was limited in all cases,10 but more recently strict dietary restrictions

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