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July 6, 1940


JAMA. 1940;115(1):30-33. doi:10.1001/jama.1940.02810270032006

The problem of tuberculosis has been involved so intimately with the conceptions of tuberculo-anaphylaxis, tuberculo-allergy and specific immunity that within recent years it was brought to fundamentally close approximation to the conceptions evolved on the theoretical bases of histamine action in the body. These actions in general were reviewed elaborately by Best and McHenry in 1931,1 when they pointed out that there appears to be a striking relation between histamine shock and anaphylactic shock as based on the observations of Dale and Laidlaw (1910-1920) and others. In 1929 Best2 showed that lung and other tissues when suspended in saline solution and incubated in the presence of toluene at 37 C. cause the disappearance of naturally occurring or added histamine. The substance or system producing this disappearance is thermolabile. In 1930 Best and McHenry3 suggested the name histaminase for a histamine-inactivating substance with the characteristic of enzymes. They

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