December 14, 1963

Council on Drugs

JAMA. 1963;186(11):1013. doi:10.1001/jama.1963.03710110065012

Vasodilator Effects of Nicotinyl Tartrate  (Roniacol Tartrate)Although nicotinyl tartrate was introduced in 1949 for proposed use as a vasodilator agent, the laboratory and clinical data concerning this drug have not been available to the Council until recently; it has been evaluated at this time in order to provide the physician with current information concerning this product. The vasodilator effects of nicotinyl tartrate are similar to those produced by large doses of nicotinic acid, which also is regarded as a weak vasodilator, and are believed to be due to its conversion to nicotinic acid in the body.Nicotinyl tartrate is the tartaric acid salt of the alcohol corresponding to nicotinic acid, and its pharmacological properties are thought to be due to its conversion to nicotinic acid in the body by oxidation. Thus, like nicotinic acid, nicotinyl tartrate, when given in adequate dosage, produces cutaneous vasodilatation, as evidenced by flushing of

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