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January 4, 1964


JAMA. 1964;187(1):54. doi:10.1001/jama.1964.03060140060017

Characteristically, children with mongolism are short. Not only is their stature retarded in childhood, but their adult height is well below average. This depression of growth appears to be directly related to delayed skeletal maturation. The short stature is a constant finding, whether the mongolism is associated with nondisjunction or with any of the various proposed mechanisms of translocation.

It is of interest to see this facet of mongolism explored in clinical studies of the type reported recently in the American Journal of Diseases of Children. In two reports, Kirschvink and his associates1 and Ray and his associates2 present controlled studies on the effect of three anabolic steriods—methyltestosterone, norethandrolone, and oxandrolone—on both height age and bone age in mongoloid children. Prior investigation into the possible use of some of these agents in various types and degrees of growth retardation has been discouraging and often confusing.

Previous studies have

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