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Clinical Notes
January 4, 1964

Coronary Artery Disease and ArteriosclerosisA Possible Method for Predicting Their Presence

JAMA. 1964;187(1):67. doi:10.1001/jama.1964.03060140073027

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MANY INVESTIGATORS BELIEVE that the predisposition to coronary disease or arteriosclerosis can be detected by means of appropriate tests made on the living patient. These investigators generally base their predictions on the study of various types of blood lipids. Other factors such as anthropological bodily types, heredity, etc, are considered relevant.

Studies Inadequate  In spite of expenditures of large sums of money, such studies apparently have not been too helpful. In fact, in one well-known and expensive study, the differences of opinion among the investigators were not resolved. Some present plans, for example the determination of lipid factors followed by an electrocardiogram (ECG), have obvious defects. Studies involving the performance of similar tests with subsequent autopsies are also difficult to interpret for various reasons. To study large population groups for years or decades creates other obvious problems and is again extremely expensive.Can anything be done to meet these objections?

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