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Letters to the Journal
January 4, 1964

Comparable Doses of Adrenal Corticosteroids

JAMA. 1964;187(1):68. doi:10.1001/jama.1964.03060140074030

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To the Editor:—  The ratio of hydrocortisone to dexamethasone and betamethasone quoted by Dr. Max Michael (JAMA185:280 [July 27] 1963) has not been confirmed by others. In the administration of adrenal corticosteroids to patients with asthma, we have found that one tablet of 0.6 mg of betamethasone is equal in antiasthmatic potency to approximately 10 mg of prednisone, or 60 mg of cortisone acetate. The mean daily doses of the three compounds producing a similar clinical response in our experience have been 1 mg of betamethasone, 17 mg of prednisone, and 106 mg of cortisone acetate (Amer J Dis Child105:127 [Feb] 1963; Amer J Dis Child106: 388 [Oct] 1963).

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