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Multiple Discipline Research Forum
February 22, 1964

Bladder Evacuation in Paraplegic Dogs by Direct Electric Stimulation

Author Affiliations

Brooklyn, NY

From the Edward Neimeth Institute for Medical Research and the Department of Surgery, Maimonides Hospital, and the Department of Surgery, State University of New York College of Medicine, Downstate Medical Center.

JAMA. 1964;187(8):595-597. doi:10.1001/jama.1964.03060210045010

EARLY RESULTS of direct electric stimulation of the urinary bladder in paraplegic dogs have been previously reported.1,2 Two stainlesssteel wire electrodes were implanted in the smooth muscle itself for application of a train of biphasic square waves generated by a stimulator. Parameters of the most effective stimulus were one to six milliseconds' duration and 15 to 35 cycles per second frequency. The best response was obtained with 4 msec and 20 cps (Fig 1). This corresponds rather well with the findings of Burghele and associates,3 as well as with those of Bradley et al.4

In experiments on 12 normal dogs and 17 animals whose lumbar spinal cords had been transected, a catheter was inserted through a small cystotomy during surgery. Intravesical pressure, registered with a strain-gauge and recorder, exceeded 40 cm of water with 2.5- to 10-v stimuli in all but two dogs. In most of the 17 paraplegic

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