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The dynamic interplay between mechanical forces such as pressure, tension, compression, and drag, and the tissues of the cardiovascular system accounts for a wide variety of conditions affecting the heart and blood vessels, according to Simon Rodbard, MD, PhD, director of cardiology at the City of Hope Medical Center in Duarte, Calif. Rodbard told The Journal that the operation of such mechanical forces determines in significant part the development of vascular scleroses, stenoses, aneurysmal and post-stenotic dilatations, endocarditis, and other conditions.
Rodbard suggested that each variety of mechanical energy acts at the cellular level to bring about a discrete change in structure. The tissue response is usually in the nature of a negative feedback which reduces the effect of the force on the cell. While this feedback ordinarily restores an equilibrium between force and local structure with beneficent results for the owner of a particular cardiovascular system, the changes may
Hydrodynamic Effects on Cell Structure Blamed for Cardiovascular Disorders. JAMA. 1964;188(2):29. doi:10.1001/jama.1964.03060280107053