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Medical News
April 13, 1964

How Do Organs Maintain Local Blood Control?

JAMA. 1964;188(2):37. doi:10.1001/jama.1964.03060280115058

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The tendency for an organ to keep blood flow in proportion to metabolic rate and to maintain a relative constant capillary hydrostatic pressure may be explained by three "currently popular" theories, according to Francis J. Haddy, MD, PhD, professor of physiology at the University of Oklahoma Medical School. Haddy, speaking before the Hahnemann Symposium on Shock and Hypotension March 18-21 in Philadelphia, said the three theories are

  • An active response to change in transmural pressure (Bayliss response);

  • An active response to change in oxygen tension; and

  • An active response to change in metabolite concentration.

"Recent evidence suggests a major role for the metabolites with a lesser role for Bayliss Response," while the "role of oxygen tension is not yet clear," he said.

Local regulation is apparent, for example, when metabolic rate, arterial pressure or venous pressure is changed in an isolated organ. Increase of metabolic rate, such

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