In a study testing the value of gastric freezing to control duodenal ulcer, about 70% of patients were palliated for short periods by a single freeze. Symptoms have recurred, however, in a progressively large percentage of patients evaluated at six weeks to nine months postfreeze. Of those who accepted a second freeze, nearly one half had return of symptoms in 6 to 12 weeks after refreeze. Acid peptic secretion was decreased for a few weeks only. No correlation was found between return of symptoms and level of acid peptic secretion. Occasional patients, without symptoms, harbored newly formed craters after freezing, thus demonstrating a danger inherent in "pain" control without persistent reduction in acid peptic secretion. Psychological reinforcement inherent in the treatment makes objective evaluation difficult.
Hitchcock CR, Bitter JE, Sutherland RD. Clinical Evaluation of Gastric Freezing for Duodenal Ulcer. JAMA. 1964;188(5):409-414. doi:10.1001/jama.1964.03060310009002