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Original Contributions
May 4, 1964

Congenital Anomalies Probably Induced by Cyclophosphamide

Author Affiliations

Calif; Torrance, Calif

Dr. Greenberg is attending physician at Harbor General Hospital, Torrance, and clinical instructor in medicine at University of California at Los Angeles Center for Health Sciences. Dr. Tanaka is chief of hematology at Harbor General Hospital and associate professor of medicine at University of California at Los Angeles Center for Health Sciences.

JAMA. 1964;188(5):423-426. doi:10.1001/jama.1964.03060310023005
Abstract

A child showing multiple congenital anomalies was born to a woman with Hodgkin's disease who was treated with cyclophosphamide during pregnancy. It is probable that the alkylating agent administered during the first trimester played a significant teratogenic role. Alkylating agents act as teratogens in animals but have not been demonstrated previously as a cause of fetal abnormalities in humans.

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