May 4, 1964


JAMA. 1964;188(5):461. doi:10.1001/jama.1964.03060310061014

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Numerous medical regimens and surgical procedures for peptic ulcer disease, all well documented with an extensive literature, provide ample evidence that this "benign" condition too frequently conquers those who would be its conquerors. It is not without reason, then, that new therapeutic measures are greeted with the trite, yet faithful, questions: Will they do what they are supposed to do? Will they stand the test of time? In few instances can original research answer all such questions. Concepts and techniques must leave the researcher's hands, undergo clinical trials, be met with unknown and variable factors, and make their way back again for reassessment.

Gastric freezing, which has undergone most of this cycle, was introduced as a radically new technique designed to be simpler than surgery, less time-consuming for patient and physician, and requiring little hospitalization. Preliminary data indicated hope for a significant reduction in morbidity and recurrences, two plagues of

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