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Clinical Notes
May 4, 1964

Hyperlipemia Following Sulfonylurea Therapy in Young Diabetics

Author Affiliations

Gainesville. Fla; Seattle; Boston

Dr. Shipp is associate professor of medicine at the University of Florida College of Medicine and was formerly an instructor in medicine at Harvard Medical School, Boston, and a fellow of the Medical Foundation. Dr. Wood is assistant professor of medicine at the University of Washington School of Medicine and was formerly a research fellow in medicine at the Harvard Medical School. Dr. Marble is assistant clinical professor of medicine at Harvard Medical School and attending physician at Joslin Clinic and New England Deaconess Hospital.

JAMA. 1964;188(5):468-470. doi:10.1001/jama.1964.03060310068018

PATIENTS with untreated diabetes mellitus often demonstrate some elevations of plasma lipids. The increased blood concentrations of free fatty acids (FFA), triglycerides, cholesterol, and phospholipids usually return to normal with treatment which improves glucose utilization.

This report describes the occurrence of severe hyperlipemia associated with lipemia retinalis and xanthomatosis in certain diabetic patients treated with sulfonylurea compounds. In each instance, the control of the patient's hyperglycemia by the sulfonylurea was inadequate. These observations emphasize the importance of adequate follow-up of carbohydrate metabolism in patients treated with oral hypoglycemic agents.

Methods  Venous blood was drawn while the patient was in the fasting state unless otherwise noted. Blood glucose was determined by the method of Somogyi,1 total lipids by the method of Folch,2 FFA by the method of Dole,3 cholesterol by the method of Abell,4 and phospholipids by the method of Sperry.5 Patients were hospitalized during the

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