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To the Editor:—
Because benzothiadiazines have been used so widely for many diverse conditions—including even obesity—any comment on the diabetogenic effect of this class of compounds is important.It is not surprising that a respected senior investigator such as Dr. Edward Freis (JAMA187:462 [Feb 8] 1964) is disturbed at the increasingly reported side effects of these agents. Everyone will agree with him as he states that "these agents are quite effective and often irreplaceable, either alone or as an adjunct in the treatment of hypertension...." Though sufficient details of studies cannot be supplied in a letter, we feel compelled nonetheless to question certain points in Dr. Freis's argument.He states that the two groups were similar in regard to race distribution and family history of diabetes, but he does not mention sex, and we believe that the Veterans Administration Cooperative Study is limited to male patients. This may
Wolff FW, Parmley WW. The Diabetogenic Activity of Benzothiadiazines. JAMA. 1964;188(5):473. doi:10.1001/jama.1964.03060310073024